Du Quoin seniors Jerel Holmes, Cory Campanella, Seth Baxter, Bryce Hamburger and Brandon Williams were all named to the 2010 Southern Illinois Coaches Associatioin's All-South Football Team, giving the Indians more players on the team than any other squad except Marion, which also had five players receive the honor (Shekeil Ivy, Austin Dickson, Matt Griffith, Aaron Adeoye and Marcus Green).

Rounding out the selections were Johnston City's Taylor Kirkman, J.R. Roberts and Austin Haynes, Carmi-White County's Logan Rogers, Fairfield's Cameron Williams, S-V-W-W's Dawson Verhines, Hamilton County's Adam Irvin and Clint Hopfinger, Chester's Danny Roth, Justin Eggemeyer and John Baughman, Mt. Vernon's Eric Heinzman and Blake Deaton, Carbondale's Kaid Koester and Jordan Bowlby, Anna-Jonesboro's Taylor Fitzgerald and Josiah Miller, Carterville's Skyler Neumann and Jeff Aldridge, Centralia's Alex Fritch, Murphysboro's Orlando Jarrett and Dylan Craig, Benton's Landon Stewart, Tyloer Leffler and Hunter Rone, Herrin's DeMarlo Harris, Zeb Williams and Brandon Bevis, and Harrisburg's Johnnie Donaldson and Isaac Behme.