The DuQuoin Indians play Illinois high school football (IHSA) as a 2010 member of the SIRR Mississippi conference. DuQuoin High School is located in Du Quoin, Illinois. Du Quoin is in Perry county. The Indians' Illinois Pigskin region is the 618 Football Region. They are coached by IHSFCA Hall of Fame Coach (Class of 2008) Al Martin entering his 23th year of coaching at DuQuoin. The school Athletic Director is John Campbell.

The schools 2010 enrollment numbers are 464. The Indians' colors are Red/Black. DuQuoin has qualified for the IHSA playoffs 26 times, the last playoff appearance was 2009. They have qualified for the playoffs 26 consecutive years.