The Breese Mater Dei (Catholic) Knights play Illinois high school football (IHSA) as an Independent. Breese Mater Dei High School is located in Breese, Illinois. Breese is in Clinton county. The Knights' Illinois Pigskin region is the 618 Football Region. They are coached by IHSFCA Hall of Fame Coach (Class of 2009) Jim Stiebel. The school Athletic Director is Dennis Trame.

The schools 2010 enrollment numbers are 848.1. The Knights' colors are Columbia Blue/White/Navy. Breese Mater Dei has qualified for the IHSA playoffs 18 times, the last playoff appearance was 2009. They have qualified for the playoffs 6 consecutive years.