The 2010 SIRR Mississippi conference has 6 member schools: Anna-Jonesboro (Anna) Wildcats, Carterville Lions, DuQuoin (Du Quoin) Indians, Nashville Hornets, Pinckneyville Panthers, Sparta Bulldogs. This is the first year for the Carterville Lions in the Southern Illinois River to River, Mississippi Division, after previously being a founding member of the Black Diamond Conference since 1949. Chester left for the BDC, after being a founding member of the SIRR Mississippi in 1993.

Few conferences in the 618 Football Region, if not the state, has as many member schools with playoff successes such as the SIRR Mississippi. While some of the achievements were made before the team joined the SIRR Miss. the appearances speak for themselves. Especially in Class 3A.

The newcomer, the Carterville Lions have a 14-0 Class 3A championship from 1996. Du Quoin has 14-0 championships (3A) from 1988 and 1992, with runner-up trophies in 1986, 1994, 1995, 2002, and 2008. Not wanting to be left out is Nashville with a runner-up in 1998 and Anna-Jonesboro has a matching set of trophies with a runner-up in 1983 and a championship trophy from 1984. A total of 4 championships, 7 runner-ups in the last 28 years. The other division, the SIRR Ohio can also boast Harrisburg as a runner-up in 1980 and the 2000 Harrisburg team (14-0) is said by many to be one of the best teams ever in the Southern half of the state.